Publications
2024
32. M. Pol, R. Thomann, Yi Thomann, C. G. Pappas*, Abiotic Acyl Transfer Cascades Driven by Aminoacyl Phosphate Esters and Self-Assembly.
J. Am. Chem. Soc. (pdf)
31. C. G. Pappas, Introducing Author Profile.
Angew. Chem. Int. Ed. (pdf)
30. M. Pol,# K. Dai,# R. Thomann, S. Moser, S. Roy, C. G. Pappas*, Guiding Transient Peptide Assemblies with Structural Elements Embedded in Abiotic Phosphate Fuels.
Angew. Chem. Int. Ed. (pdf)
2023
29. K. Dai,# M. Pol,# L. Saile, A. Sharma, Liu, B. R. Thomann, J. Trefs, J, D. Qiu, S. Moser, S. Wiesler,, B. Balzer, T. Hugel, H. Jessen, C. G. Pappas*, Spontaneous and Selective Peptide Elongation in Water Driven by Aminoacyl Phosphate Esters and Phase Changes.
J. Am. Chem. Soc. (pdf)
28. V. Maric, L. Yang, X. Li, G. Santiago, C. G. Pappas, X. Qiu, J. Dijksman, K. Mikhailov, P. Van Rijn, S. Otto, Tailorable and biocompatible supramolecular‐based hydrogels featuring two dynamic covalent chemistries.
Angew. Chem. Int. Ed. (pdf)
2022
27. B. Liu, J. Wu, M. Geerts, O. Markovitch, C. G. Pappas, K. Liu, S. Otto, Out-of-Equilibrium Self-Replication Allows Selection for Dynamic Kinetic Stability in a System of Competing Replicators.
Angew. Chem. Int. Ed. (pdf)
26. A. S. Pina, L. Morgado, K. L. Duncan, S. Carvalho, H. F. Carvalho, A. J. M. Barbosa, B. de P. Mariz, I. P. Moreira, D. Kalafatovic, B. M. Morais Faustino, V. Narang, T. Wang, C. G. Pappas, I. Ferreira, A. C. A. Roque, R. V. Ulijn, Discovery of phosphotyrosine-binding oligopeptides with supramolecular target selectivity
Chem. Sci. (pdf)
2021
25. C. G. Pappas,* B. Liu,I. Marić, J. Ottelé, A. Kiani, M. L. van der Klok,P. R. Onck and S. Otto*,Two Sides of the Same Coin: Emergence of Foldamers and Self-Replicators from Dynamic Combinatorial Libraries.
J. Am. Chem. Soc. (pdf)
24. B. Liu, M. A. Beatty, C. G. Pappas, K. Liu, J. Ottelé and S. Otto, Self-Sorting in Dynamic Combinatorial Libraries Leads to the Co-Existence of Foldamers and Self-Replicators
Angew. Chem. Int. Ed. (pdf)
2020
23. C. G. Pappas, P. Mandal, B. Liu, B. Kauffmann, X. Miao, D. Komáromy, W. Hoffmann, C. Manz, R. Chang, K. Liu, K. Pagel, I. Huc and S. Otto, Emergence of Low-Symmetry Foldamers from Single Monomers.
Nat. Chem. (pdf)
22. C. G. Pappas, A sound approach to self-assembly.
Nat. Chem. (pdf)
21. B. Liu, # C. G. Pappas, # J. Ottelé, G. Schaeffer, C. Jurissek, P. F. Pieters, M. Altay and S. Otto, Spontaneous Emergence of Self-Replicating Molecules Containing Nucleobases and Amino Acids.
J. Am. Chem. Soc. (pdf)
20. C. G. Pappas,* N. Wijerathne, J. Kishore Sahoo, A. Jain, D. Kroiss, I. R. Sasselli, A. Pina, A. Lampel and Rein V. Ulijn,* Spontaneous aminolytic cyclization and self-assembly of dipeptide methyl esters in water.
ChemSystemsChem (pdf)
2019
19. B. Liu, C. G. Pappas, E. Zangrando, N. Demitri, P. J. Chmielewski and S. Otto, Complex Molecules That Fold Like Proteins Can Emerge Spontaneously.
J. Am. Chem. Soc. (pdf)
· Selected as ACS Editors’ Choice and JACS spotlight: Spontaneous Emergence of Complex Molecules that Can Fold Like Proteins. (pdf)
· Highlighted in Chemistry World, Synthetic molecules fold up into abiotic proteins. (pdf)
· Highlighted in Chemical & Engineering News, Macrocycle folds up like a protein. (pdf)
2018
18. S. Ishiguro, A. Kawabata, A. Zulbaran-Rojas, K. Monson, D. Uppalapati, N. Ohta, M. Inui, C. G. Pappas, A. G. Tzakos and M. Tamura, Co-treatment with a C1B5 peptide of protein kinase Cγ and a low dose of gemcitabine strongly attenuated pancreatic cancer growth in mice through T cell activation.
Biochem. Biophys. Res. Commun. (pdf)
2017
17. C. Zhang, R. Shafi, A. Lampel, D. MacPherson, C. G Pappas, V. Narang, T. Wang, C. Maldarelli and R. V. Ulijn, Switchable Hydrolase Based on Reversible Formation of Supramolecular Catalytic Site Using a Self-Assembling Peptide.
Angew. Chem. Int. Ed. (pdf)
16. J. K. Sahoo, C. G. Pappas, I. R. Sasselli, Y. M. Abul-Haija and R. V. Ulijn, Biocatalytic self-assembly cascades.
Angew. Chem. Int. Ed. (pdf)
15. B. M. Matysiak, P. Nowak, I. Cvrtila, C. G. Pappas, B. Liu, D. Komáromy and S. Otto, Antiparallel Dynamic Covalent Chemistries.
J. Am. Chem. Soc. (pdf)
2016
14. C. G. Pappas, R. Shafi, I. R. Sasselli, H. Siccardi, T. Wang, V. Narang, R. Abzalimov, N. Wijerathne and R. V. Ulijn, Dynamic peptide libraries for the discovery of supramolecular nanomaterials.
Nat. Nanotechnol. (pdf)
· News and Views article, Self-assembly: Materials from a peptide soup.
Nat. Nanotechnol. (pdf)
· Preview article, Thermodynamic Selection of Supramolecular Nanomaterials from Dynamic Peptide Libraries.
Chem (pdf)
· Highlighted in Science Daily, Phys.Org, Nanowerk, The Engineer, Materials Today, Scicasts, Survival of the fittest in Materials Discovery. (pdf)
13. R. Sasselli, C. G. Pappas, E. Matthews, T. Wang, N. T. Hunt, R. V. Ulijn and T. Tuttle, Using experimental and computational energy equilibration to understand hierarchical self-assembly of Fmoc-dipeptide amphiphiles.
Soft Matter (pdf)
2015
12. C. G. Pappas, I. R. Sasselli and R. V. Ulijn, Biocatalytic pathway selection in transient tripeptide nanostructures.
Angew. Chem. Int. Ed. (pdf)
11. C. G. Pappas, T. Mutasa, P. W. J. M. Frederix, S. Fleming, S. Debnath, S. Bai, S. M. Kelly, A. Gachagan and R. V. Ulijn, Transient supramolecular reconfiguration of peptide nanostructures using ultrasound.
Mater. Horiz. (pdf)
10. P. W. J .M. Frederix, G. G. Scott, Y. M. Abul-Haija, D. Kalafatovic, C. G. Pappas, N. Javid, N. T. Hunt, R. V. Ulijn and T. Tuttle, Exploring the sequence space for (tri-) peptide self-assembly to design and discover new hydrogels.
Nat. Chem. (pdf)
· News and Views article, Searching the sequence space.
Nat. Chem. (pdf)
9. C. G. Pappas, P. W. J. M. Frederix, T. Mutasa, S. Fleming, Y. M. Abul-Haija, S. M. Kelly, A. Gachagan, D. Kalafatovic, J. Trevino, R. V. Ulijn and S. Bai, Alignment of nanostructured tripeptide gels by directional ultrasonication.
Chem. Commun. (pdf)
2014
7. F. Magnani, C. G. Pappas, T. Crook, V. Magafa, P. Cordopatis, S. Ishiguro, N. Ohta, J. Selent, S. Bosnyak, E. S. Jones, I. P. Gerothanassis, M. Tamura, R. E. Widdop and A. G. Tzakos, Electronic sculpting of ligand-GPCR subtype selectivity: the case of angiotensin.
ACS Chem. Bio. (pdf)
6. S. Bai, S. Debnath, N. Javid, P. W. J. M. Frederix, S. Fleming, C. G. Pappas and R. V. Ulijn, Differential self-assembly and tuneable emission of aromatic peptide bola-amphiphiles containing perylene bisimide in polar solvents including water.
Langmuir (pdf)
5. T. Karampelas, O. Argyros, N. Sayyad, K. Spyridaki, C. G. Pappas, K. Morgan, G. Kolios, R. P. Millar, G. Liapakis, A. G. Tzakos, D. Fokas and C. Tamvakopoulos, GnRH-gemcitabine conjugates for the treatment of androgen-independent prostate cancer: pharmacokinetic enhancements combined with targeted drug delivery.
Bioconjug. Chem. (pdf)
4. C. G. Pappas,# Y. M. Abul-Haija,# A. Flack, P. W. J. M. Frederix and R. V. Ulijn., Tuneable Fmoc–Phe–(4-X)–Phe–NH2 nanostructures by variable electronic substitution.
Chem. Commun. (pdf)
3. P. Stathopoulos, S. Papas, C. G. Pappas, V. Mousis, N. Sayyad, V. Theodorou, A. G Tzakos and V. Tsikaris, Side reactions in the SPPS of Cys-containing peptides.
Amino Acids (pdf)
2013
2. V. G. Kontogianni, P. Charisiadis, A. Primikyri, C. G. Pappas, V. Exarchou, A. G. Tzakos and I. P. Gerothanassis, Hydrogen bonding probes of phenol-OH groups.
Org. Bio. Chem. (pdf)
1. C. G. Pappas, A. G. Tzakos, I. P. Gerothanassis, On the Hydration State of Amino Acids and Their Derivatives at Different Ionization States: A Comparative Multinuclear NMR and Crystallographic Investigation.
J. Amino Acids (pdf)
#co-first author, *corresponding author